MEK Inhibitor RO4987655
Information
- Drug Name
- MEK Inhibitor RO4987655
- Description
- Entry(CIViC)
- 5
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| melanoma | BRAF V600 BRAF V600 | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 2 | 24947927 | Detail |
| melanoma | BRAF WILD TYPE BRAF WILD TYPE | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
2 | 24947927 | Detail |
| melanoma | NRAS MUTATION NRAS MUTATION | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 2 | 24947927 | Detail |
| lung non-small cell carcinoma | KRAS MUTATION KRAS MUTATION | B |
Predictive
|
Does Not Support
|
N/A | Somatic | 1 | 24947927 | Detail |
| colorectal cancer | KRAS MUTATION KRAS MUTATION | B |
Predictive
|
Does Not Support
|
N/A | Somatic | 1 | 24947927 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Phase I expansion and pharmacodynamic study of ora... | BRAF | BRAF V600 BRAF V600 | Sensitivity | true | CIViC Evidence | detail |
| Phase I expansion and pharmacodynamic study of the... | BRAF | BRAF WILD TYPE BRAF WILD TYPE | Sensitivity | true | CIViC Evidence | detail |
| Phase I expansion and pharmacodynamic study of the... | NRAS | NRAS MUTATION NRAS MUTATION | Sensitivity | true | CIViC Evidence | detail |
| Phase I expansion and pharmacodynamic study of the... | KRAS | KRAS MUTATION KRAS MUTATION | N/A | false | CIViC Evidence | detail |
| Phase I expansion and pharmacodynamic study of the... | KRAS | KRAS MUTATION KRAS MUTATION | N/A | false | CIViC Evidence | detail |